Description

GEODON is available as the Capsules of GEODON (ziprasidone the hydrochloride) for the oral administration and as GEODON for the Injection (ziprasidone mesylate) for intramuscular injection. Ziprasidone is a psychotropic agent who belongs without report chemically to phenothiazine or to antipsychotic agents butyrophenone. He has a molecular weight of 412.94 (the free base), with the following chemical name: 5-[2-[4-(1,2-benzisothiazol-3-yl) - 1-piperazinyl] the ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one.

The Capsules of GEODON contain a monohydrochloride, a salt of monohydroxide of ziprasidone. Chemically, ziprasidone the monohydroxide of hydrochloride is 5-[2-[4-(1,2-benzisothiazol-3-yl) - 1-piperazinyl] the ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, the monohydroxide. Empirical formula is C21H21CLN4OS · HCL · H2O and its molecular weight is 467.42. The monohydroxide of hydrochloride of Ziprasidone is a white in the slightly pink powder.

The Capsules of GEODON are given for the oral administration in the (white / white) (blue / white) capsules and of 80 mgs (blue / blue), of 60 mgs (blue / white), of 40 mgs of 20 mgs. The Capsules of GEODON contain the monohydroxide of hydrochloride ziprasidone, the lactose, the pregelatinized the starch and the magnesium stearate.

GEODON for Injection contains a form of lyophilized of ziprasidone mesylate trihydrate. Chemically, ziprasidone mesylate trihydrate the ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one is 5-[2-[4-(1,2-benzisothiazol-3-yl) - 1-piperazinyl], methanesulfonate, trihydrate. Empirical formula is C21H21CLN4OS · CH3SO3H · 3H2O and its molecular weight is 563.09.

GEODON for Injection is available in a vial of simple dose as ziprasidone mesylate (20 mgs ziprasidone / mL when reconstructed according to the instructions of tag - see Preparation for the Administration) for the intramuscular administration. Every millilitre of ziprasidone mesylate for injection (when reconstructed) contains 20 mgs of ziprasidone and 4.7 mgs of acid methanesulfonic solubilized of 294 mgs of sulfobutylether β-cyclodextrin the sodium (SBECD).